Graduate Program in Neuroscience
NEURO 101:CORE COURSE A: Cellular and Molecular Neuroscience
This course covers introductory lectures to the anatomy of the central nervous system, basic principles of development, the physiology of neurons, neurophysiology, neuronal circuits, cell structure and cell-cell communication, signal transduction and metabolism of the nervous system.
NEURO 102: CORE COURSE B: Systemic Neuroscience
This course covers the organization and neuronal circuits of various systems such as vision, motor, oculomotor, audition, chemosensory, spinal motor systems, neuromuscular junction, mesolimbic system. Also taught is the pathogenesis of Parkinson’s disease, memory disorders (Alzheimer’s disease, tauropathies).
NEURO 103: Principles and methods used for the study of the Nervous System
The Methodology in Neuroscience course aims to familiarize the graduate students with the experimental approaches used in the study of the nervous system. In addition, it aims to make them familiar with the terminology used in neuroscience publications. The methods taught cover a large spectrum of approaches starting from the molecular analysis of genes important in the nervous system to modern drug design. The course focuses on the understanding of the basic principles underlying the relevant methodologies that are taught.
NEURO 201:Experimental and computational aspects of Neurophysiology
Experimental aspects: Ion channel properties, neurotransmitter modulation of ion channels, ion channel plasticity, ion channels in disease
Computational aspects: The first mathematical models of neural cells, Cable theory, ion channel modeling (Hodgkin and Huxley equations), detailed compartmental models of neurons, the role of dendrites and active membrane properties in synaptic integration and information coding
NEURO 202:Neurochemistry / Neuropharmacology
This course provides a general overview of the biochemical properties of the nervous system and covers in-depth different neurotransmitters systems, their receptors and effector systems, and their role in health and disease conditions. The course is organized around lectures and student presentations.
NEURO 203: Psychopharmacology
Psychopharmacology is the major treatment modality in Psychiatry, which has dramatically changed psychiatric practice since the early 50s. Antipsychotic, antianxiety, and antidepressant agents can modify the behavior of psychiatric patients and for this reason they have greatly affected the management of the hospitalized mentally ill, enabling their de-institutionalization, rehabilitation in the community and even their full recovery. The “Psychopharmacology” course teaches the actions of these drugs and their effects on mood, thinking and behavior. The course focuses primarily on the chemical interactions with the brain with emphasis on synaptic aspects of the action mechanisms of drugs and how this translates into changes in physiological or psychological function and behavior. Relevant aspects of the neurobiology of mental disorders are also discussed.
NEURO204: Neuroregenerative Pharmacology
Aim of the course is to introduce the graduate students to the basic aspects of de-/re-generative biology and pharmacology of the Nervous System. Molecular and cellular mechanisms of neuronal proliferation, differentiation and cell death are describing. In addition, the receptors and signaling pathways that mediate these effects are presented and more specific cellular events (like axonal growth, neurite elongation, re-myelination or adult neurogenesis) are analyzed. In combination with the study of the aforementioned mechanisms, the development of neurodegenerative diseases and the pharmacological approach of these are discussed extensively, in order to uncover the therapeutic potential of novel pharmacological methods and agents for neurological diseases.
NEURO 205: Lab Rotation
NEURO 206: Neuropsychology: Theory and Implementation
The aim of the module is to gain advanced knowledge and understanding of classical and modern theories in neuropsychology, neuropsychological functions and the way they modulate behaviour as well as the clinical profile and the aetiology of neuropsychological syndromes. The students will be taught on a) research methods in neuropsychology, b) anatomy, functions and related disorders after cerebral lobe damage, c) cerebral asymmetry and disconnection syndromes, d) symptoms and aetiology of neurological, psychiatric and neurodevelopmental disorders and e) processes of neuroplasticity and functional recovery.
NEURO207: Neurobiology and psychopharmacology of reward, addiction and depression
The present module examines topics on brain reward circuits and their role in normal and abnormal physiological functions of the organism. The module examines the neurobiology and psychopharmacology of brain reward circuits and their association with depression and drug abuse, i.e. two diseases that are associated with the dysfunction of brain reward circuits. Several research data will be presented and interrelated.
Among the topics expected to be covered: 1) Neuronal circuits that mediate reward and reward-mediated behaviors 2) Changes at the neuronal level after receiving a reinforcement and the subsequent feeling of pleasure 3) The role of brain reward systems in depression and mania 4) Anhedonia in depression 5) The effects of addictive drugs on brain reward circuits and the neuroadaptations induced by chronic drug abuse 6) Associations between neuroadaptive changes, compulsive drug seeking and addiction.
NEURO 301:Developmental Neurobiology
The course covers the basic principles of the development of the nervous system in different model systems. In particular, topics such as neural stem cells in development and in the adult, neural cell type specification, neural tube patterning and migration,
axon pathfinding, cell death, neurotrophins and their receptors, ageing are covered. The course is organized around lectures and student presentations.
NEURO302Molecular Basis of Neurological and Psychiatric Diseases
NEURO303: Lab Rotation
NEURO304: Lab Rotation
NEURO305: Drug Develpment
NEURO 306: Statistics
NEURO307: Physiology of the Hypothalamic-Pituitary-Adrenal (HPA) axis
Topics covered: anatomy, organization and function of hypothalamus, pituitary, and adrenal gland; Corticotropin-Releasing Hormone family of peptides-CRH receptors and their antagonists-Role of AVP on the physiology of the HPA axis; biosynthesis, structure and function of ACTH-ACTH receptors-Opioid Receptors; biosynthesis, structure and function of adrenal steroid hormones-steroid hormone receptors; neurotransmitters and their receptors in the HPA axis-Interactions of adrenal medullary and cortical hormones in response to stress;rRole of cytokines on the function of the HPA axis
NEURO308: Common pathways in neurodegenerative diseases and in psychiatric disorders revised