Nikolaos Pitsikas, PhD

Associate Professor in Pharmacology

Laboratory of Pharmacology

School of Medicine

University of Thessaly



Research Interests


N. Pitsikas is Associate Professor of Pharmacology in the Medical School of the University of Thessaly at Larissa. His research interests are focused in the field of Behavioural Pharmacology. In particular, he investigates the role of nitric oxide, of 5-HT2c and 5-HT6 receptors in cognition, anxiety and schizophrenia. He also studies the psychotomimetic effects of different N-methyl-D-aspartate (NMDA) receptor antagonists and the role exerted by agonists and antagonists of the metabotropic mGlu2/3 receptor in cognition, anxiety, schizophrenia and obsessive compulsive disorder. Finally, he studies the role exerted by the plant Crocus Sativus and its extracts in the treatment of different pathologies of the central nervous system

He is involved in a vast number of research programs either as scientific responsible or as a team member. He has different scientific collaborations both in Greece (University of Ioannina, Agricultural University of Athens, Biomedical Research Foundation, Academy of Athens) and with foreign scientific research centers in Italy and in USA.


Selected recent publications


1.      A. Boultadakis, N. Pitsikas. Anesthetic ketamine impairs ratsí recall of previous information. The nitric oxide synthase inhibitor L-NAME antagonizes the ketamine-induced recognition memory deficits. Anesthesiology, vol. 114: 1345-1353, 2011.

2.      A. Boultadakis and N. Pitsikas. Effects of the nitric oxide synthase inhibitor L-NAME on recognition and spatial memory deficits produced by different NMDA receptor antagonistst in the rat. Neuropsychopharmacology, vol. 35: 2357-2366, 2010.

3.      A. Boultadakis, G. Georgiadou, N. Pitsikas. Effects of the nitric oxide synthase inhibitor L-NAME on different memory components as assessed in the object recognition task in the rat. Behav. Brain Res., vol. 207: 208-214, 2010.

4.      N. Pitsikas, A. Boultadakis. Pre-training administration of anesthetic ketamine differentially affects ratsí spatial and non-spatial recognition memory. Neuropharmacology, vol. 57: 1-9, 2009.

5.      N. Pitsikas, A.E. Rigamonti, S.G. Cella, N. Sakellaridis, E.E. Muller. The nitric oxide donor molsidomine antagonizes age-related memory deficits in the rat. Neurobiol. Aging, vol. 26: 261-266, 2005.