George Panagis, PhD

Associate Professor in Biopsychology

University of Crete

Department of Psychology

Laboratory of Behavioral Neuroscience



His main interests lie in the following fields:


Neural basis of brain stimulation reward.


Interactions between drugs of abuse and brain reward systems.


The role of endogenous cannabinoid system in behavior and reward.


Effects of mood stabilizers on brain reward.


Effects of physical exercise on brain reward system and behaviour.


Selected Publications

1.                  Panagis G., Hildebrand B.E., Svensson T.H. & Nomikos G.G. (2000) Selective c-fos induction and decreased dopamine release in the the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Synapse, 35, 15-25.

2.                  Panagis G., Kastellakis A., Spyraki C. & Nomikos G.G (2000) Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine- induced potentiation of brain stimulation reward, Psychopharmacology, 149, 388-396.

3.                  Vlachou, S., Stamatopoulou, F., Nomikos, G.G. and Panagis, G. (2008) Enhancement of endocannabinoid neurotransmission through CB1 cannabinoid receptors counteracts the reinforcing and psychostimulant effects of cocaine, International Journal of Neuropsychopharmacology, 11, 905-923.

4.                  Mavrikaki, M., Nomikos, G.G., & Panagis, G. (2009). Effects of Mood Stabilizers on Brain Reward Processes in Rats: Studies Using the Intracranial Self-Stimulation Paradigm, European Neuropsychopharmacology, 19, 205-214.

5.                  Mavrikaki, M., Markaki, E., Nomikos, G.G., & Panagis, G. (2010). Chronic WIN55,212-2 elicits sustained and conditioned increases in intracranial self-stimulation thresholds in the rat, Behavioural Brain Research, 209, 114-118.

6.                  Katsidoni, V., Apazoglou, K., & Panagis, G. (2011).Role of serotonin 5-HT2A and 5-HT2C receptors on brain stimulation reward and the reward-facilitating effect of cocaine, Psychopharmacology, 213, 337-354.