Achilleas Gravanis, PhD

Professor of Pharmacology

School of Medicine, University of Crete

Collaborating Researcher, IESL-FORTH





Interplay between the brain hormonal micro-environment and neurotrophins during development and aging. Molecular mechanisms in neurodegeneration and neurogenesis: development of synthetic small molecules with neuroprotective and neurogenic properties. Bioengineering of 3D scaffolds for neuronal cell cultures: development of neuroimplants and neurobiosensors.



Recent publications

1.      Charalampopoulos I, Tsatsanis C,  Dermitzaki E, Alexaki I, Castanas E, Margioris AN, Gravanis A. (2004). Dehydroepiandrosterone and allopregnanolone protect sympathoadrenal cells against apoptosis, via Bcl-2 antiapoptotic proteins. Proc Natl Acad Sci USA, 101:8209-8214

2.      Charalampopoulos I, Dermitzaki E, Vardouli L, Tsatsanis C, Stournaras C, Margioris A, Gravanis A.  (2005) Dehydroepiandrosterone Sulfate and Allopregnanolone Directly Stimulate Catecholamine Production via Induction of Tyrosine Hydroxylase and Secretion by Affecting Actin Polymerization. Endocrinology. 146:3309-3318

3.      Charalampopoulos I, Alexaki IV, Lasaridis I, Dermitzaki E, Avlonitis N,  Tsatsanis C, Calogeropoulou T, Margioris A, Castanas E, Gravanis A.  (2006). G-protein-associated membrane binding sites mediate the neuroprotective effect of Dehydroepiandrosterone. FASEB J, 20:577-579

4.      Calogeropoulou T, Avlonitis N,  Minas V, Pantzou A, Alexi X, Charalampopoulos I, Zervou M, Vergou V, Lazaridis I, Alexis MN, Gravanis A. (2009). Novel dehydroepiandrosterone derivatives with anti-apoptotic, neuroprotective activity.  J Med Chem, 52:6569-6587

5.      Lazaridis I, Charalampopoulos I, Alexaki VI, Avlonitis N, Pediaditakis I, Efstathopoulos P, Calogeropoulou T, Castanas E, Gravanis A. (2011) Neurosteroids interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol 9(4):e1001051